Photochemical stability of antimalarial. I. Hydroxychloroquine
Identifieur interne : 003196 ( Main/Exploration ); précédent : 003195; suivant : 003197Photochemical stability of antimalarial. I. Hydroxychloroquine
Auteurs : Hanne Hjorth T Nnesen [Norvège] ; Anne-Lise Grislingaas [Norvège] ; Soo On Woo [Singapour] ; Jan Karlsen [Norvège]Source :
- International Journal of Pharmaceutics [ 0378-5173 ] ; 1988.
English descriptors
- Teeft :
- Antimalarial, Antimalarial drugs, Chloroform, Chloroquine, Degradation, Degradation products, Free radicals, Further analysis, Hemmens, Hplc, Hplc chromatogram, Hydroxychloroquine, Hydroxychloroquine compound, Hydroxychloroquine sulphate, Isopropanol, Mass fragments, Mobile phase, Photochemical degradation, Photochemical stability, Photodegradation products, Retinal toxicity, Stationary phase, Sulphate.
Abstract
Abstract: Hydroxychloroquine has been reported to cause toxic reactions which may be ascribed to the photochemical degradation of the substance. The possibility of photochemical dechlorination has also been indicated. The effect of light at a wavelength of 240–600 m on aqueous solutions of hydroxychloroquine was investigated. The four decomposition products obtained were isolated by means of preparative TLC. The purity of the samples was examined by HPLC. The samples were identified by mass-spectrometry (EI, CI and high-resolution MS) and nuclear magnetic resonance spectroscopy (13C- and 1H-NMR). Under the given experimental conditions a photodechlorination of hydroxychloroquine was not observed.
Url:
DOI: 10.1016/0378-5173(88)90276-1
Affiliations:
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The possibility of photochemical dechlorination has also been indicated. The effect of light at a wavelength of 240–600 m on aqueous solutions of hydroxychloroquine was investigated. The four decomposition products obtained were isolated by means of preparative TLC. The purity of the samples was examined by HPLC. The samples were identified by mass-spectrometry (EI, CI and high-resolution MS) and nuclear magnetic resonance spectroscopy (13C- and 1H-NMR). Under the given experimental conditions a photodechlorination of hydroxychloroquine was not observed.</div></front></TEI><affiliations><list><country><li>Norvège</li><li>Singapour</li></country><region><li>Østlandet</li></region><settlement><li>Oslo</li></settlement></list><tree><country name="Norvège"><region name="Østlandet"><name sortKey="T Nnesen, Hanne Hjorth" sort="T Nnesen, Hanne Hjorth" uniqKey="T Nnesen H" first="Hanne Hjorth" last="T Nnesen">Hanne Hjorth T Nnesen</name></region><name sortKey="Grislingaas, Anne Lise" sort="Grislingaas, Anne Lise" uniqKey="Grislingaas A" first="Anne-Lise" last="Grislingaas">Anne-Lise Grislingaas</name><name sortKey="Karlsen, Jan" sort="Karlsen, Jan" uniqKey="Karlsen J" first="Jan" last="Karlsen">Jan Karlsen</name></country><country name="Singapour"><noRegion><name sortKey="Woo, Soo On" sort="Woo, Soo On" uniqKey="Woo S" first="Soo On" last="Woo">Soo On Woo</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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